The Wales international has suffered a stress reaction in his spine and now needs to rest before undergoing a scan.
Edwards has been dogged by various injury problems this season, including thigh and hamstring setbacks.
He impressed when he returned to action in the 4-0 win over Blackpool but missed the weekend draw with Tottenham and now faces another spell on the sidelines.
The head of Wolves' medical department, Steve Kemp, said: "Dave complained of lower back stiffness after the Blackpool game.
"As a result, he had a scan which showed up the stress reaction in his lumbar spine.
"With these findings it's not worth risking him carrying on playing with the injury as it could develop into something more serious.
"It's actually fortunate we found the problem quite early, and we now intend to manage the injury by treating Dave over the next month after which we will re-assess."
Source: PA
Source: PA